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Scientific Research

Evogene and Tel Aviv University’s Blavatnik Center for Drug Discovery Announce Joint Initiative to Accelerate AI-Driven Small-Molecule Drug Discovery

Evogene and Tel Aviv University’s Blavatnik Center for Drug Discovery have announced a strategic initiative to accelerate AI-driven small-molecule drug discovery emerging from Israel’s academic research ecosystem. Facilitated by Ramot, Tel Aviv University’s technology transfer company, the collaboration is designed to support researchers and scientific entrepreneurs working on novel disease targets. The initiative combines the Blavatnik Center for Drug Discovery’s experimental infrastructure and translational drug discovery capabilities with Evogene’s computational chemistry platform, including its ChemPass AI™ generative engine. Selected projects will receive support through an integrated design, make, test, and analyze workflow intended to help move promising biological insights toward viable drug development programs. By bringing together academic science, experimental validation, and AI-enabled molecule design, the collaboration addresses a critical gap in early-stage therapeutic innovation. The initiative reflects the Blavatnik Center’s mission to advance pioneering medical research from the laboratory toward potential patient benefit.

Nine Breakthrough Projects Selected for 2026 Blavatnik Accelerator Awards

The Blavatnik Fund for Innovation at Yale has announced nine recipients of its 2026 Accelerator Awards, supporting early-stage life science research with strong translational potential. The awards provide funding and mentorship to help Yale researchers generate validation data and advance discoveries toward future development. This year’s cohort spans women’s health, oncology, gastroenterology, immunology, orthopedics, reproductive health, metabolic disease, and regenerative medicine. The projects focusing on women’s health include approaches to continuous estrogen monitoring, endometriosis, post-menopausal osteoporosis, and fertility preservation. Selected through a competitive review and pitch process, the awards help promising faculty move breakthrough ideas closer to practical application. The program reflects the Foundation’s commitment to accelerating scientific innovation and helping university research address urgent health challenges.

Stanford Scientists Reverse Age-Related Memory Loss by Targeting the Gut

A new Stanford Medicine study, partly supported by the Blavatnik Family Fellowship Fund at the Stanford University School of Medicine, suggests that age-related memory decline may be influenced not only by changes in the brain, but also by changes in the gut. Published in Nature, the study found that shifts in the gut microbiome of older mice can trigger gastrointestinal inflammation, disrupting signals sent through the vagus nerve to the hippocampus, a brain region central to memory formation. When young mice were exposed to older microbiomes, they showed declines in memory and navigation; when researchers restored gut-brain communication in older mice, memory performance improved. The findings identify a pathway linking gastrointestinal aging, immune response, vagus nerve activity, and hippocampal function. Although the research was conducted in mice, it points to new ways of understanding cognitive decline through the gut-brain connection.

By Studying Fruit Flies, Rachel Wilson Is Changing How We Understand the Brain

Harvard Medicine profiles Rachel Wilson, the Joseph B. Martin Professor of Basic Research in the Field of Neurobiology in the Blavatnik Institute at Harvard Medical School, whose work with fruit flies is advancing understanding of how nervous systems produce behavior. For more than two decades, Wilson has helped pioneer techniques that allow researchers to observe activity in individual neurons as fruit flies sense, move, and navigate their environments. Her lab’s research has revealed important principles of sensory processing, internal navigation, and the neural circuits that help animals understand where they are and where to go next. At the Blavatnik Institute at HMS, Wilson is also contributing to the field of connectomics, using detailed maps of the fruit fly nervous system to study how distributed neural networks give rise to coordinated action. Wilson was also a 2014 Laureate in Life Sciences in the inaugural Blavatnik National Awards for Young Scientists. Her work reflects the Foundation’s commitment to supporting exceptional scientists and institutions pursuing fundamental discoveries about biology, behavior, and human health.

Mount Sinai Health System Launches Women’s Health Video Podcast HERology

Mount Sinai Health System has launched HERology, a new women’s health video podcast designed to offer accessible, expert-led conversations on care across the lifespan and powered by the Carolyn Rowan Center for Women’s Health and Wellness, which is opening in May 2026 on Manhattan’s Upper East Side. The show is cohosted by Joanne L. Stone, MD, along with Leslee Shaw, PhD, Director of the Blavatnik Family Women’s Health Research Institute, and Anna Barbieri, MD, with Anuradha Lala, MD, serving as a contributing co-host. The launch reflects Mount Sinai’s broader effort to connect clinical expertise, research, and public education in women’s health through a multidisciplinary platform. The podcast will be released every two weeks across major streaming platforms, extending Mount Sinai’s outreach beyond the clinical setting.

Aegis Ventures and Wavelet Medical Aim to Redefine the Standard of Care in Fetal Medicine

Wavelet Medical has partnered with Aegis Ventures to advance a non-invasive, AI-powered fetal brain monitoring platform that detects fetal distress in real time and helps prevent avoidable brain injury at birth. The collaboration, supported by $7 million in seed funding, aims to advance the technology from laboratory research to broader clinical testing and commercialization, with the goal of improving outcomes for both mothers and babies while reducing unnecessary interventions. It's a significant step toward a more precise and preventive standard of care in fetal medicine, with Wavelet already being tested at three clinical sites and preparing for expanded trials. Wavelet received the Blavatnik Fund for Innovation at Yale Award in 2023, an accelerator managed by Yale Ventures, which supported its early development.

How Yale Ventures is ‘Accelerating’ Innovation

Yale News recently highlighted how Yale Ventures is helping move academic research toward real-world application, with the Blavatnik Fund for Innovation at Yale supporting faculty-led work in the life sciences as part of that broader effort. Since its founding in 2017, the Fund has supported 98 projects and awarded $24 million, helping pair promising research with the practical guidance, mentorship, and translational support needed to advance ideas beyond the lab.

‘I think I know how to fix this.’

A Harvard Medical School team led by Andrew Kruse has engineered a longer-lasting form of the hormone relaxin—an approach that could help address heart failure with preserved ejection fraction (HFpEF), a hard-to-treat condition affecting roughly 1 million people in the U.S. By converting relaxin from a two-chain to a one-chain molecule and fusing it to an antibody Fc-domain to extend its half-life, the researchers advanced a promising concept toward therapeutic use, with support from Harvard’s Office of Technology Development and the Blavatnik Biomedical Accelerator through pilot and development funding and business guidance. That early translational backing helped de-risk the science, enabling Kruse to license the technology and launch Tectonic Therapeutic, where the resulting candidate (TX45) is now in a Phase 2 clinical trial and being explored for pulmonary hypertension linked to heart failure and other serious cardiopulmonary conditions. As Kruse noted, “The Blavatnik Accelerator is really what allowed us to go from a pure research compound to something that was ultimately a clinical candidate.”

Blavatnik Fund for Innovation at Yale to Support 12 Life Sciences Projects in 2026 Spanning Oncology, Diagnostics, Neurology, Kidney and Liver Disease

The Blavatnik Fund for Innovation at Yale will support 12 faculty-led life sciences projects in 2026 that address critical challenges in oncology, neurodegeneration, diagnostics, and kidney and liver disease, advancing discoveries toward meaningful health outcomes for patients. Since 2017, the partnership between Yale and the Blavatnik Fund has supported more than 98 unique projects, spawned 46 new ventures, and enabled nine investigational new drug clearances, reflecting a sustained commitment to translating bold science into real-world solutions. Awardees in this cycle are pursuing innovations from novel therapeutics to next-generation diagnostics and platform technologies, each with the potential to reshape how disease is understood and treated. Yale’s Vice Provost for Research, Michael Crair, observed that “through the Blavatnik Fund for Innovation at Yale, we have built a robust ecosystem of entrepreneurs that helps faculty advance discoveries with real potential for societal impact.” He further emphasized that at a time when early-stage research investment is essential, the ongoing partnership with the Foundation “ensures that promising innovations do not stall in the lab” but move closer to patients.

AI Foundation Model Aims to Make Stem Cell Therapies More Predictable

Researchers at the Blavatnik Institute at Harvard Medical School are contributing to the development of a new artificial-intelligence “foundation model” to improve the predictability and reproducibility of stem cell research, a major hurdle in regenerative medicine. By analyzing large biological datasets, the model seeks to identify the underlying rules governing cell differentiation, helping scientists anticipate outcomes and reduce reliance on trial-and-error approaches. The work has led to the formation of Cellular Intelligence, which was co-founded by researchers in the Blavatnik Institute at Harvard Medical School to translate these insights into practical tools for the field. Early work benefited from shared space and infrastructure at the Blavatnik Harvard Life Lab Longwood, illustrating how supportive translational environments can help bridge discovery science and real-world application.

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